Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0866 | 0.085 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.0053 | 0.2492 | 0.2546 |
Schistosoma mansoni | protein kinase | 0.0125 | 0.7146 | 0.7299 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0021 | 0.0429 | 0.0422 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0024 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0021 | 0.0429 | 0.0413 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0021 | 0.0429 | 0.0413 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0148 | 0.8694 | 0.8692 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0019 | 0.0351 | 0.0335 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0158 | 0.9323 | 0.9322 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0086 | 0.4678 | 0.477 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0025 | 0.0712 | 0.0711 |
Echinococcus granulosus | NCK adaptor protein | 0.0021 | 0.0429 | 0.0422 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0163 | 0.9605 | 0.9811 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0086 | 0.4678 | 0.477 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0019 | 0.0351 | 0.0335 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0866 | 0.085 |
Brugia malayi | Protein kinase domain containing protein | 0.0148 | 0.8694 | 0.8692 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0028 | 0.0883 | 0.0868 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0024 | 0.0676 | 0.0674 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0014 | 0.0017 | 0.5 |
Brugia malayi | Variant SH3 domain containing protein | 0.0021 | 0.0429 | 0.0413 |
Echinococcus granulosus | activin receptor type | 0.0079 | 0.4183 | 0.4263 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0024 | 0.0676 | 0.069 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | protein kinase | 0.0165 | 0.979 | 1 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0165 | 0.979 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0024 | 0.0676 | 0.066 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0158 | 0.9323 | 0.9322 |
Schistosoma mansoni | tyrosine kinase | 0.0086 | 0.4678 | 0.4779 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0017 | 0.0017 |
Brugia malayi | hypothetical protein | 0.0148 | 0.8658 | 0.8656 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0351 | 0.0335 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0158 | 0.9323 | 0.9523 |
Brugia malayi | protein C17H12.11 | 0.0148 | 0.8658 | 0.8656 |
Onchocerca volvulus | 0.0027 | 0.0866 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | insulin receptor | 0.0053 | 0.2492 | 0.2533 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0019 | 0.0351 | 0.0335 |
Schistosoma mansoni | nck2/grb4 | 0.0021 | 0.0429 | 0.0438 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0021 | 0.0429 | 0.0413 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0075 | 0.3936 | 0.401 |
Echinococcus multilocularis | 0.0048 | 0.2202 | 0.2236 | |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0165 | 0.979 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Brugia malayi | Protein kinase domain containing protein | 0.0053 | 0.2492 | 0.248 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0021 | 0.0429 | 0.0438 |
Brugia malayi | activin receptor:ISOTYPE=IIA. | 0.0121 | 0.6935 | 0.693 |
Schistosoma mansoni | protein kinase | 0.0078 | 0.4146 | 0.4236 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0165 | 0.979 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0021 | 0.0429 | 0.0438 |
Schistosoma mansoni | tyrosine kinase | 0.0083 | 0.4432 | 0.4527 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | NCK adaptor protein | 0.0021 | 0.0429 | 0.0422 |
Schistosoma mansoni | tyrosine kinase | 0.0083 | 0.4432 | 0.4527 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0019 | 0.0334 | 0.0317 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.0053 | 0.2492 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0086 | 0.4678 | 0.477 |
Onchocerca volvulus | Protein cycle homolog | 0.0019 | 0.0351 | 0.3942 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0148 | 0.8694 | 0.8692 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Schistosoma mansoni | tyrosine kinase | 0.0083 | 0.4432 | 0.4527 |
Echinococcus multilocularis | activin receptor type | 0.0079 | 0.4183 | 0.4263 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.9323 | 0.9524 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0429 | 0.0413 |
Schistosoma mansoni | adapter molecule crk | 0.0021 | 0.0429 | 0.0438 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0021 | 0.0429 | 0.0438 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0163 | 0.9605 | 0.9811 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0021 | 0.0429 | 0.0422 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0053 | 0.2492 | 0.2533 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0019 | 0.0351 | 0.0359 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | SRC-1 | 0.0024 | 0.0676 | 0.066 |
Schistosoma mansoni | tyrosine kinase | 0.0152 | 0.8946 | 0.9138 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8658 | 0.8656 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0028 | 0.0883 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Schistosoma mansoni | protein kinase | 0.0125 | 0.7146 | 0.7299 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0028 | 0.0883 | 0.0887 |
Brugia malayi | SRC-1 | 0.0024 | 0.0676 | 0.066 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0158 | 0.9323 | 0.9523 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | protein kinase | 0.0125 | 0.7146 | 0.7295 |
Echinococcus granulosus | insulin receptor | 0.0053 | 0.2492 | 0.2533 |
Schistosoma mansoni | tyrosine kinase | 0.0086 | 0.4678 | 0.4779 |
Echinococcus granulosus | protein kinase | 0.0125 | 0.7146 | 0.7295 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Echinococcus granulosus | c src tyrosine kinase | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0024 | 0.0676 | 0.0674 |
Brugia malayi | Variant SH3 domain containing protein | 0.0021 | 0.0429 | 0.0413 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0053 | 0.2492 | 0.2533 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0053 | 0.2492 | 0.248 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0169 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0024 | 0.0676 | 0.0674 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.