Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.4432 | 0.4527 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0024 | 0.0676 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0084 | 0.4678 | 0.477 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0144 | 0.8694 | 0.8692 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0019 | 0.0351 | 0.0335 |
Echinococcus granulosus | NCK adaptor protein | 0.002 | 0.0429 | 0.0422 |
Schistosoma mansoni | tyrosine kinase | 0.0153 | 0.9323 | 0.9524 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.002 | 0.0429 | 0.0438 |
Brugia malayi | Variant SH3 domain containing protein | 0.002 | 0.0429 | 0.0413 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0019 | 0.0351 | 0.0359 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Echinococcus granulosus | activin receptor type | 0.0076 | 0.4183 | 0.4263 |
Brugia malayi | Variant SH3 domain containing protein | 0.002 | 0.0429 | 0.0413 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.4432 | 0.4527 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.2492 | 0.2546 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0024 | 0.0712 | 0.0711 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0024 | 0.0676 | 0.0674 |
Onchocerca volvulus | Protein cycle homolog | 0.0019 | 0.0351 | 0.3942 |
Loa Loa (eye worm) | SRC-1 | 0.0024 | 0.0676 | 0.066 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8658 | 0.8656 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0027 | 0.0883 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0866 | 0.085 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0153 | 0.9323 | 0.9523 |
Schistosoma mansoni | protein kinase | 0.0121 | 0.7146 | 0.7299 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0051 | 0.2492 | 0.2533 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0163 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0024 | 0.0676 | 0.0674 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Brugia malayi | Protein kinase domain containing protein | 0.0051 | 0.2492 | 0.248 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.4678 | 0.4779 |
Echinococcus granulosus | protein kinase | 0.0121 | 0.7146 | 0.7295 |
Echinococcus multilocularis | protein kinase | 0.0121 | 0.7146 | 0.7295 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0024 | 0.0676 | 0.066 |
Echinococcus multilocularis | NCK adaptor protein | 0.002 | 0.0429 | 0.0422 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0024 | 0.0676 | 0.0674 |
Echinococcus granulosus | insulin receptor | 0.0051 | 0.2492 | 0.2533 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.002 | 0.0429 | 0.0438 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0158 | 0.9605 | 0.9811 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.8946 | 0.9138 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0051 | 0.2492 | 0.248 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0024 | 0.0676 | 0.0674 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0158 | 0.9605 | 0.9811 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0084 | 0.4678 | 0.477 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0019 | 0.0351 | 0.0335 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0019 | 0.0351 | 0.0335 |
Brugia malayi | protein C17H12.11 | 0.0143 | 0.8658 | 0.8656 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0027 | 0.0883 | 0.0887 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.002 | 0.0429 | 0.0438 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0014 | 0.0017 | 0.5 |
Schistosoma mansoni | adapter molecule crk | 0.002 | 0.0429 | 0.0438 |
Schistosoma mansoni | protein kinase | 0.0076 | 0.4146 | 0.4236 |
Onchocerca volvulus | 0.0027 | 0.0866 | 1 | |
Echinococcus multilocularis | c src tyrosine kinase | 0.0024 | 0.0676 | 0.0674 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.2492 | 0.2546 |
Schistosoma mansoni | protein kinase | 0.0121 | 0.7146 | 0.7299 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.002 | 0.0429 | 0.0413 |
Echinococcus granulosus | c src tyrosine kinase | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0866 | 0.085 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0153 | 0.9323 | 0.9322 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0084 | 0.4678 | 0.477 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0429 | 0.0413 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.002 | 0.0429 | 0.0413 |
Brugia malayi | hypothetical protein | 0.0143 | 0.8658 | 0.8656 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0019 | 0.0334 | 0.0317 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.002 | 0.0429 | 0.0422 |
Echinococcus multilocularis | 0.0047 | 0.2202 | 0.2236 | |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.002 | 0.0429 | 0.0413 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.016 | 0.979 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0073 | 0.3936 | 0.401 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0024 | 0.0676 | 0.0674 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0051 | 0.2492 | 0.2533 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Schistosoma mansoni | nck2/grb4 | 0.002 | 0.0429 | 0.0438 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.4432 | 0.4527 |
Brugia malayi | SRC-1 | 0.0024 | 0.0676 | 0.066 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Echinococcus multilocularis | insulin receptor | 0.0051 | 0.2492 | 0.2533 |
Schistosoma mansoni | tyrosine kinase | 0.0024 | 0.0676 | 0.069 |
Echinococcus multilocularis | activin receptor type | 0.0076 | 0.4183 | 0.4263 |
Brugia malayi | activin receptor:ISOTYPE=IIA. | 0.0118 | 0.6935 | 0.693 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.002 | 0.0429 | 0.0422 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.016 | 0.979 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0024 | 0.0676 | 0.0674 |
Schistosoma mansoni | protein kinase | 0.016 | 0.979 | 1 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.016 | 0.979 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0153 | 0.9323 | 0.9322 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0024 | 0.0676 | 0.0674 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0153 | 0.9323 | 0.9523 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0351 | 0.0335 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0144 | 0.8694 | 0.8692 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0027 | 0.0883 | 0.0868 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.4678 | 0.4779 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0017 | 0.0017 |
Brugia malayi | Protein kinase domain containing protein | 0.0144 | 0.8694 | 0.8692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.