Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein cycle homolog | 0.002 | 0.0351 | 0.3942 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0149 | 0.8694 | 0.8692 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0087 | 0.4678 | 0.477 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.002 | 0.0351 | 0.0335 |
Schistosoma mansoni | tyrosine kinase | 0.0083 | 0.4432 | 0.4527 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0676 | 0.069 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0025 | 0.0676 | 0.069 |
Echinococcus granulosus | activin receptor type | 0.0079 | 0.4183 | 0.4263 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0025 | 0.0676 | 0.0674 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Brugia malayi | Variant SH3 domain containing protein | 0.0021 | 0.0429 | 0.0413 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0021 | 0.0429 | 0.0438 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.9323 | 0.9524 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0429 | 0.0413 |
Schistosoma mansoni | tyrosine kinase | 0.0083 | 0.4432 | 0.4527 |
Brugia malayi | Variant SH3 domain containing protein | 0.0021 | 0.0429 | 0.0413 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.002 | 0.0351 | 0.0335 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0025 | 0.0676 | 0.0674 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0025 | 0.0676 | 0.0674 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0025 | 0.0712 | 0.0711 |
Schistosoma mansoni | tyrosine kinase | 0.0053 | 0.2492 | 0.2546 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0025 | 0.0676 | 0.0674 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0866 | 0.085 |
Schistosoma mansoni | protein kinase | 0.0125 | 0.7146 | 0.7299 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0159 | 0.9323 | 0.9523 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0028 | 0.0883 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.8658 | 0.8656 |
Loa Loa (eye worm) | SRC-1 | 0.0025 | 0.0676 | 0.066 |
Echinococcus granulosus | insulin receptor | 0.0053 | 0.2492 | 0.2533 |
Echinococcus multilocularis | NCK adaptor protein | 0.0021 | 0.0429 | 0.0422 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0025 | 0.0676 | 0.066 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0025 | 0.0676 | 0.0674 |
Brugia malayi | Protein kinase domain containing protein | 0.0053 | 0.2492 | 0.248 |
Echinococcus multilocularis | protein kinase | 0.0125 | 0.7146 | 0.7295 |
Schistosoma mansoni | tyrosine kinase | 0.0087 | 0.4678 | 0.4779 |
Echinococcus granulosus | protein kinase | 0.0125 | 0.7146 | 0.7295 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0025 | 0.0676 | 0.0674 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0025 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.017 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0053 | 0.2492 | 0.2533 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0021 | 0.0429 | 0.0438 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0164 | 0.9605 | 0.9811 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0025 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0025 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0025 | 0.0676 | 0.0674 |
Brugia malayi | hypothetical protein | 0.002 | 0.0351 | 0.0335 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0053 | 0.2492 | 0.248 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0676 | 0.069 |
Schistosoma mansoni | tyrosine kinase | 0.0153 | 0.8946 | 0.9138 |
Echinococcus granulosus | NCK adaptor protein | 0.0021 | 0.0429 | 0.0422 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0025 | 0.0676 | 0.0674 |
Brugia malayi | Protein kinase domain containing protein | 0.0149 | 0.8694 | 0.8692 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0028 | 0.0883 | 0.0887 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.002 | 0.0351 | 0.0335 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.002 | 0.0351 | 0.0359 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0087 | 0.4678 | 0.477 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0164 | 0.9605 | 0.9811 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0025 | 0.0676 | 0.0674 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0025 | 0.0676 | 0.0674 |
Onchocerca volvulus | 0.0028 | 0.0866 | 1 | |
Schistosoma mansoni | protein kinase | 0.0079 | 0.4146 | 0.4236 |
Schistosoma mansoni | adapter molecule crk | 0.0021 | 0.0429 | 0.0438 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0014 | 0.0017 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0676 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0866 | 0.085 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0021 | 0.0429 | 0.0422 |
Echinococcus granulosus | c src tyrosine kinase | 0.0025 | 0.0676 | 0.0674 |
Schistosoma mansoni | protein kinase | 0.0125 | 0.7146 | 0.7299 |
Schistosoma mansoni | tyrosine kinase | 0.0053 | 0.2492 | 0.2546 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0149 | 0.8694 | 0.8692 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0021 | 0.0429 | 0.0413 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0019 | 0.0334 | 0.0317 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0021 | 0.0429 | 0.0438 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0087 | 0.4678 | 0.477 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0159 | 0.9323 | 0.9322 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0053 | 0.2492 | 0.2533 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0025 | 0.0676 | 0.0674 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0075 | 0.3936 | 0.401 |
Echinococcus multilocularis | 0.0048 | 0.2202 | 0.2236 | |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0167 | 0.979 | 1 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0021 | 0.0429 | 0.0413 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0021 | 0.0429 | 0.0422 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0167 | 0.979 | 1 |
Echinococcus multilocularis | activin receptor type | 0.0079 | 0.4183 | 0.4263 |
Brugia malayi | activin receptor:ISOTYPE=IIA. | 0.0122 | 0.6935 | 0.693 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0021 | 0.0429 | 0.0413 |
Echinococcus multilocularis | insulin receptor | 0.0053 | 0.2492 | 0.2533 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0676 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0025 | 0.0676 | 0.0674 |
Brugia malayi | SRC-1 | 0.0025 | 0.0676 | 0.066 |
Schistosoma mansoni | tyrosine kinase | 0.0083 | 0.4432 | 0.4527 |
Schistosoma mansoni | nck2/grb4 | 0.0021 | 0.0429 | 0.0438 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0025 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0025 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0159 | 0.9323 | 0.9322 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0167 | 0.979 | 1 |
Schistosoma mansoni | protein kinase | 0.0167 | 0.979 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0025 | 0.0676 | 0.0674 |
Brugia malayi | hypothetical protein | 0.0149 | 0.8658 | 0.8656 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0017 | 0.0017 |
Schistosoma mansoni | tyrosine kinase | 0.0087 | 0.4678 | 0.4779 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0028 | 0.0883 | 0.0868 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0159 | 0.9323 | 0.9523 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0334 | 0.0317 |
Brugia malayi | protein C17H12.11 | 0.0149 | 0.8658 | 0.8656 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.