Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prolyl endopeptidase | 0.0141 | 0.4673 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0183 | 0.7394 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0141 | 0.4673 | 0.632 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0183 | 0.7394 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0183 | 0.7394 | 0.7394 |
Echinococcus granulosus | prolyl endopeptidase | 0.0141 | 0.4673 | 0.632 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0183 | 0.7394 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0141 | 0.4673 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0183 | 0.7394 | 0.5109 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0141 | 0.4673 | 0.632 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0141 | 0.4673 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0183 | 0.7394 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0223 | 1 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0141 | 0.4673 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0141 | 0.4673 | 0.4673 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0141 | 0.4673 | 0.632 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0115 | 0.2907 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.