Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0078 | 0.1972 | 1 |
Trypanosoma brucei | GMP reductase | 0.0078 | 0.1972 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0078 | 0.1972 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0078 | 0.1972 | 0.1972 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0078 | 0.1972 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0078 | 0.1972 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0078 | 0.1972 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.0264 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0078 | 0.1972 | 0.5 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0264 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0241 | 0.9017 | 0.8776 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0078 | 0.1972 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0264 | 1 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0073 | 0.1772 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0264 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0078 | 0.1972 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0078 | 0.1972 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0241 | 0.9017 | 0.8776 |
Leishmania major | guanosine monophosphate reductase | 0.0078 | 0.1972 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0078 | 0.1972 | 0.1972 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0073 | 0.1772 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0041 | 0.0369 | 0.0954 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0078 | 0.1972 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0078 | 0.1972 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0073 | 0.1772 | 0.8869 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0078 | 0.1972 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.