Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0181 | 0.9299 | 0.9299 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | hedgehog | 0.019 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.9299 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.5967 | 0.6417 |
Echinococcus multilocularis | geminin | 0.0181 | 0.9299 | 0.9299 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.9299 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.