Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | flavodoxin | 0.009 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.057 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0146 | 0.1154 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0236 | 0.3033 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0119 | 0.0596 | 0.004 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0236 | 0.3033 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0209 | 0.2475 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0236 | 0.3033 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0236 | 0.3033 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0117 | 0.0558 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0236 | 0.3033 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0236 | 0.3033 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0236 | 0.3033 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0117 | 0.0558 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0236 | 0.3033 | 1 |
Leishmania major | p450 reductase, putative | 0.0236 | 0.3033 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0236 | 0.3033 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0236 | 0.3033 | 0.3033 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0236 | 0.3033 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0209 | 0.2475 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.057 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0236 | 0.3033 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0236 | 0.3033 | 0.2621 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3033 | 0.3033 |
Brugia malayi | FAD binding domain containing protein | 0.0146 | 0.1154 | 0.1154 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0236 | 0.3033 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0146 | 0.1154 | 0.0631 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0236 | 0.3033 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0146 | 0.1154 | 0.1154 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0236 | 0.3033 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0236 | 0.3033 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0209 | 0.2475 | 0.8159 |
Brugia malayi | flavodoxin family protein | 0.0236 | 0.3033 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0236 | 0.3033 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0209 | 0.2475 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0236 | 0.3033 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0236 | 0.3033 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0209 | 0.2475 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.