TDR Targets

Basic information

Technical information

TDR Targets ID: 894423
Name: STK280922
MW: 283.297 | Formula: C17H14FNO2
H donors: 0 H acceptors: 2 LogP: 2.36 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C2C(C(=O)N1c1ccc(cc1)F)C1C3(C2C=C1)CC3
InChi: 1S/C17H14FNO2/c18-9-1-3-10(4-2-9)19-15(20)13-11-5-6-12(14(13)16(19)21)17(11)7-8-17/h1-6,11-14H,7-8H2
InChiKey: GANLQAXBMFJFQF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

EU-0036375
AG-690/34440051
BAS 01002807

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Chromo domain	0.0011	0.0072	0.0097
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.2329	0.2329
Onchocerca volvulus		0.0011	0.0072	0.0072
Schistosoma mansoni	chromobox protein	0.0011	0.0072	0.0097
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0072	0.0072
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0.0072	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0329	0.0329
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0072	0.5
Plasmodium falciparum	heterochromatin protein 1	0.0011	0.0072	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0072
Onchocerca volvulus		0.0011	0.0072	0.0072
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3121	0.4196
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.6842	1
Echinococcus granulosus	tar DNA binding protein	0.0061	0.3121	0.4562
Schistosoma mansoni	hypothetical protein	0.0033	0.1403	0.1886
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0072	0.0105
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.3493	1
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.3121	0.3121
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1403	0.1403
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0072	0.0097
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.2329	0.2329
Onchocerca volvulus		0.003	0.12	0.12
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0011	0.0072	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0329	0.0442
Brugia malayi	chromobox protein homolog 3	0.0038	0.1695	0.1695
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0329	0.048
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0072	0.0072
Schistosoma mansoni	hypothetical protein	0.0015	0.0329	0.0442
Entamoeba histolytica	hypothetical protein	0.0035	0.1515	1
Echinococcus granulosus	chromobox protein 1	0.0067	0.3493	0.5105
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0072	0.0097
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0011	0.0072	0.0105
Echinococcus multilocularis	chromobox protein 1	0.0067	0.3493	0.4695
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0072	0.0072
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3121	0.4196
Schistosoma mansoni	hypothetical protein	0.0011	0.0072	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2329	0.2329
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0174	1	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0072	0.0097
Schistosoma mansoni	hypothetical protein	0.0015	0.0329	0.0442
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0072	0.0105
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.1869	0.5254
Brugia malayi	TAR-binding protein	0.0061	0.3121	0.3121
Echinococcus multilocularis	chromobox protein 1	0.0067	0.3493	0.4695
Loa Loa (eye worm)	hypothetical protein	0.0174	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0072
Schistosoma mansoni	chromobox protein	0.0011	0.0072	0.0097
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0329	0.0442
Entamoeba histolytica	hypothetical protein	0.0035	0.1515	1
Brugia malayi	Heterochromatin protein 1	0.0067	0.3493	0.3493
Schistosoma mansoni	hypothetical protein	0.0015	0.0329	0.0442
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.1515	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0072
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0072	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0072
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0329	0.0442
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.1869	0.5254
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.1403	0.1403
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0072	0.0097
Schistosoma mansoni	chromobox protein	0.0067	0.3493	0.4695
Brugia malayi	RNA binding protein	0.0061	0.3121	0.3121
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0011	0.0072	0.5
Schistosoma mansoni	chromobox protein	0.0067	0.3493	0.4695
Schistosoma mansoni	thyroid hormone receptor	0.0132	0.7439	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.2329	0.2329
Brugia malayi	hypothetical protein	0.0011	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1695	0.1695
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0329	0.0442
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0072	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3121	0.4196
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0072
Echinococcus granulosus	GPCR family 2	0.0015	0.0329	0.048
Entamoeba histolytica	hypothetical protein	0.0035	0.1515	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0329	0.0329
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.1515	0.2036
Entamoeba histolytica	hypothetical protein	0.0035	0.1515	1
Loa Loa (eye worm)	helicase	0.0011	0.0072	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.1026	0.2789
Echinococcus granulosus	chromobox protein 2	0.0011	0.0072	0.0105
Loa Loa (eye worm)	heterochromatin protein 1	0.0067	0.3493	0.3493
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3121	0.4196
Onchocerca volvulus		0.0011	0.0072	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.1695	0.4746
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.3121	0.3121
Echinococcus granulosus	Chromo domain	0.0011	0.0072	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0072
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.1869	0.1869
Schistosoma mansoni	thyroid hormone receptor	0.0132	0.7439	1
Schistosoma mansoni	hypothetical protein	0.0122	0.6842	0.9197
Brugia malayi	SET domain containing protein	0.0011	0.0072	0.0072
Brugia malayi	hypothetical protein	0.0035	0.1515	0.1515
Plasmodium vivax	heterochromatin protein 1, putative	0.0011	0.0072	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.1695	0.1695
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3121	0.4196
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0132	0.7439	1
Loa Loa (eye worm)	CHromoDomain protein family member	0.0011	0.0072	0.0072
Loa Loa (eye worm)	RNA binding protein	0.0061	0.3121	0.3121
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0011	0.0072	0.0097
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.3493	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0011	0.0072	0.0097
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0072	0.0072
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0072	0.0097
Loa Loa (eye worm)	hypothetical protein	0.003	0.12	0.12
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.1695	0.4746
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.1026	0.2789
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0011	0.0072	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0329	0.048
Schistosoma mansoni	hypothetical protein	0.0035	0.1515	0.2036
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0011	0.0072	0.5
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0072	0.0097
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.1515	0.2036
Brugia malayi	Protein cec-1.	0.0011	0.0072	0.0072
Brugia malayi	CHD4 protein	0.0011	0.0072	0.0072
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.6842	0.9197
Echinococcus granulosus	chromobox protein 1	0.0067	0.3493	0.5105
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.3121	0.4196
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.3121	0.3121
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0329	0.0329

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 894423