Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin D (A01 family) | 0.015 | 0.1496 | 0.1496 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0127 | 0.1148 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0067 | 0.0242 | 0.0242 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0217 | 0.2502 | 0.2502 |
Echinococcus granulosus | glycogen phosphorylase | 0.0217 | 0.2502 | 0.2502 |
Leishmania major | carbonic anhydrase-like protein | 0.0127 | 0.1148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0051 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0127 | 0.1148 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0217 | 0.2502 | 1 |
Schistosoma mansoni | peroxidasin | 0.0067 | 0.0242 | 0.0242 |
Schistosoma mansoni | glycogen phosphorylase | 0.0094 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0217 | 0.2502 | 0.2502 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Schistosoma mansoni | peroxidasin | 0.0067 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0067 | 0.0242 | 0.0242 |
Schistosoma mansoni | glycogen phosphorylase | 0.0217 | 0.2502 | 0.2502 |
Echinococcus granulosus | glycogen phosphorylase | 0.0217 | 0.2502 | 0.2502 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0067 | 0.0242 | 0.0242 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0217 | 0.2502 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0217 | 0.2502 | 0.2316 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0051 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0217 | 0.2502 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0127 | 0.1148 | 0.1148 |
Plasmodium vivax | plasmepsin IV, putative | 0.0051 | 0 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0217 | 0.2502 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0127 | 0.1148 | 0.1148 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0127 | 0.1148 | 0.0929 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0127 | 0.1148 | 0.1148 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Plasmodium falciparum | plasmepsin II | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0067 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0127 | 0.1148 | 0.0929 |
Schistosoma mansoni | glycogen phosphorylase | 0.0217 | 0.2502 | 0.2502 |
Echinococcus granulosus | peroxidasin | 0.0067 | 0.0242 | 0.0242 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0217 | 0.2502 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0714 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0286 | 0.3547 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0217 | 0.2502 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0714 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.6439 | 0.6439 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0286 | 0.3547 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0714 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0714 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0217 | 0.2502 | 0.2502 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0217 | 0.2502 | 0.2502 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0127 | 0.1148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.015 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0217 | 0.2502 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Plasmodium falciparum | plasmepsin I | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Plasmodium falciparum | plasmepsin VI | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0217 | 0.2502 | 0.2502 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0067 | 0.0242 | 0.0242 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0127 | 0.1148 | 0.1148 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.6439 | 0.6439 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0127 | 0.1148 | 0.1148 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0127 | 0.1148 | 0.1148 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0067 | 0.0242 | 0.0242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.