Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0592 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.006 | 0 | 0.5 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0592 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.006 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.006 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0092 | 0.0601 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.0592 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0092 | 0.0601 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0592 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.006 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.