Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0204 | 0.039 | 0.5 |
Onchocerca volvulus | 0.3584 | 1 | 1 | |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0184 | 0.0331 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0067 | 0 | 0.5 |
Leishmania major | DNA topoisomerase ii | 0.0184 | 0.0331 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.3584 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0199 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0199 | 0.0134 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.3584 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0204 | 0.039 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.3584 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0184 | 0.0331 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0184 | 0.0331 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0204 | 0.039 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.1453 | 0.3941 | 0.3696 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0111 | 0.0124 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0067 | 0 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.2131 | 0.5868 | 0.57 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0204 | 0.039 | 0.0326 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.3584 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0204 | 0.039 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0067 | 0 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0195 | 0.0364 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0204 | 0.039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3584 | 1 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.3584 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.3584 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0184 | 0.0331 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.3584 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0067 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.