Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0091 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0056 | 0 | 0.5 |
Onchocerca volvulus | 0.0091 | 1 | 0.5 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0091 | 1 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0091 | 1 | 1 |
Onchocerca volvulus | 0.0091 | 1 | 0.5 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0091 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0091 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0091 | 1 | 0.5 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0091 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0056 | 0 | 0.5 |
Onchocerca volvulus | 0.0091 | 1 | 0.5 | |
Schistosoma mansoni | tyrosinase precursor | 0.0091 | 1 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0091 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0 | 0.5 |
Onchocerca volvulus | 0.0091 | 1 | 0.5 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0056 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.