Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0348 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Echinococcus multilocularis | laminin | 0.0348 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0348 | 1 | 0.5 |
Echinococcus granulosus | laminin | 0.0348 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0348 | 1 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0348 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0348 | 1 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0348 | 1 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0348 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0348 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0348 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.