Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0064 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0064 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0064 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0064 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0064 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.016 | 1 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0064 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0064 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0064 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0064 | 0 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.016 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0064 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0064 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.