Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0222 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase | 0.6185 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase | 0.6185 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.614 | 0.9925 | 0.9925 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.1899 | 0.2812 | 0.2812 |
Loa Loa (eye worm) | hypothetical protein | 0.1632 | 0.2364 | 0.2364 |
Loa Loa (eye worm) | TK protein kinase | 0.6185 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1899 | 0.2813 | 0.2813 |
Onchocerca volvulus | 0.0345 | 0.0207 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.