Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0242 | 0.0977 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0977 | 0.5592 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0861 | 0.5455 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0348 | 0.1747 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0348 | 0.1747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1343 | 0.7685 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0348 | 0.1747 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0977 | 0.6292 | 0.6292 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0348 | 0.1747 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0348 | 0.1747 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0348 | 0.1747 | 0.3202 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0861 | 0.5455 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0292 | 0.1343 | 0.7685 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0348 | 0.1747 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0348 | 0.1747 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0242 | 0.0977 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0977 | 0.5592 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.149 | 1 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0348 | 0.1747 | 0.1747 |
Schistosoma mansoni | DNA topoisomerase II | 0.0348 | 0.1747 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0348 | 0.1747 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0242 | 0.0977 | 0.1791 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.149 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0292 | 0.1343 | 0.7685 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0348 | 0.1747 | 0.1747 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0861 | 0.5455 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0348 | 0.1747 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0242 | 0.0977 | 0.1791 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0242 | 0.0977 | 0.1791 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.149 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0348 | 0.1747 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0301 | 0.1409 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0861 | 0.5455 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0348 | 0.1747 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0513 | 0.2938 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.149 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0861 | 0.5455 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.149 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.149 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.