Detailed information for compound 902678

Basic information

Technical information
  • TDR Targets ID: 902678
  • Name: 1-(4,5-dichloro-2-methylphenyl)sulfonyl-3-met hylpyrazole
  • MW: 305.18 | Formula: C11H10Cl2N2O2S
  • H donors: 0 H acceptors: 3 LogP: 3.48 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccn(n1)S(=O)(=O)c1cc(Cl)c(cc1C)Cl
  • InChi: 1S/C11H10Cl2N2O2S/c1-7-5-9(12)10(13)6-11(7)18(16,17)15-4-3-8(2)14-15/h3-6H,1-2H3
  • InChiKey: PSBWZSXTXKPRMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4,5-dichloro-2-methyl-phenyl)sulfonyl-3-methyl-pyrazole
  • A4126/0175908
  • ZINC04744887

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0462 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1589 0.211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1589 0.211
Brugia malayi Calcitonin receptor-like protein seb-1 0.0269 0.546 0.546
Echinococcus multilocularis GPCR, family 2 0.0085 0.1148 0.1524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1589 0.211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1589 0.211
Schistosoma mansoni hypothetical protein 0.0357 0.7532 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.1589 0.1589
Schistosoma mansoni hypothetical protein 0.0085 0.1148 0.1524
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0269 0.546 0.546
Echinococcus granulosus geminin 0.0357 0.7532 1
Brugia malayi latrophilin 2 splice variant baaae 0.0184 0.3464 0.3464
Echinococcus multilocularis geminin 0.0357 0.7532 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0599 0.0599
Schistosoma mansoni gabp alpha 0.0075 0.0913 0.1212
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0976 0.1295
Brugia malayi Fli-1 protein 0.0228 0.45 0.45
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.1589 0.1589
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0127 0.0169
Loa Loa (eye worm) hypothetical protein 0.0085 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0184 0.3464 0.3464
Schistosoma mansoni hypothetical protein 0.0085 0.1148 0.1524
Brugia malayi Latrophilin receptor protein 2 0.0085 0.1148 0.1148
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1448 0.1922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1589 0.211
Schistosoma mansoni hypothetical protein 0.0085 0.1148 0.1524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1589 0.211
Echinococcus granulosus GPCR family 2 0.0085 0.1148 0.1524
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.1148 0.1148
Brugia malayi Ets-domain containing protein 0.0075 0.0913 0.0913
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.1148 0.1524
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.1148 0.1524
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0127 0.0169
Loa Loa (eye worm) hypothetical protein 0.0269 0.546 0.546
Schistosoma mansoni hypothetical protein 0.0085 0.1148 0.1524
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0913 0.1212
Schistosoma mansoni hypothetical protein 0.0357 0.7532 1
Schistosoma mansoni hypothetical protein 0.0184 0.3464 0.4599
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1589 0.211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0051 0.0353 0.0353
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0913 0.0913
Schistosoma mansoni ets-related 0.0228 0.45 0.5974
Brugia malayi jmjC domain containing protein 0.0098 0.1448 0.1448
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.1148 0.1524
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0269 0.546 0.546
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.1148 0.1524
Brugia malayi Ets-domain containing protein 0.0075 0.0913 0.0913
Loa Loa (eye worm) fli-1 protein 0.0228 0.45 0.45
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1448 0.1922
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0913 0.1212
Loa Loa (eye worm) hypothetical protein 0.0064 0.0658 0.0658

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.