Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0042 | 0.1911 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2185 | 0.2185 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0047 | 0.225 | 0.9057 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.1911 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0042 | 0.1911 | 0.8493 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2185 | 0.971 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0042 | 0.1911 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2185 | 0.971 |
Plasmodium vivax | apical sushi protein, putative | 0.0047 | 0.225 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1334 | 0.1334 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2185 | 0.2185 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2484 | 0.9441 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.1911 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2185 | 0.971 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0047 | 0.225 | 1 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0047 | 0.225 | 0.855 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0042 | 0.1911 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0221 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2185 | 0.971 |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.1911 | 0.1728 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.1911 | 1 |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0221 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.1911 | 0.1911 |
Brugia malayi | hypothetical protein | 0.0047 | 0.225 | 0.9057 |
Brugia malayi | hypothetical protein | 0.0047 | 0.225 | 0.9057 |
Loa Loa (eye worm) | inositol-1 | 0.0042 | 0.1911 | 0.7262 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0042 | 0.1911 | 1 |
Brugia malayi | Sushi domain | 0.0047 | 0.225 | 0.9057 |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0047 | 0.225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Brugia malayi | hypothetical protein | 0.0047 | 0.225 | 0.9057 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0047 | 0.225 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2185 | 0.2185 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0047 | 0.225 | 0.9057 |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0047 | 0.225 | 0.9057 |
Brugia malayi | Inositol-1 | 0.0042 | 0.1911 | 0.7692 |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1334 | 0.5371 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0221 | 0.084 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.1911 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0042 | 0.1911 | 0.8493 |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2632 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2484 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.1911 | 0.1911 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Plasmodium falciparum | apical sushi protein | 0.0047 | 0.225 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2185 | 0.8302 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0047 | 0.225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1334 | 0.5071 |
Brugia malayi | hypothetical protein | 0.0047 | 0.225 | 0.9057 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.1911 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2484 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0042 | 0.1911 | 0.8329 |
Brugia malayi | hypothetical protein | 0.0047 | 0.225 | 0.9057 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0038 | 0.159 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.225 | 0.855 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0047 | 0.225 | 0.225 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0047 | 0.225 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2185 | 0.8794 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0221 | 0.0983 |
Brugia malayi | hypothetical protein | 0.0047 | 0.225 | 0.9057 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0038 | 0.159 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0221 | 0.0221 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0221 | 0.0983 |
Trypanosoma brucei | RNA helicase, putative | 0.0153 | 1 | 1 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0047 | 0.225 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0221 | 0.089 |
Onchocerca volvulus | 0.0047 | 0.225 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2484 | 0.9441 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.