Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0166 | 0.7048 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0203 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0166 | 0.7048 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0166 | 0.7048 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0166 | 0.7048 | 0.7048 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0166 | 0.7048 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0166 | 0.7048 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0166 | 0.7048 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0166 | 0.7048 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0166 | 0.7048 | 0.8934 |
Plasmodium falciparum | carbonic anhydrase | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0166 | 0.7048 | 0.8934 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.789 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0166 | 0.7048 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0166 | 0.7048 | 0.7048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.