Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0039 | 0 | 0.5 | |
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.006 | 0.4497 | 1 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.006 | 0.4497 | 0.5 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.006 | 0.4497 | 0.5 |
Leishmania major | modification methylase-like protein | 0.006 | 0.4497 | 0.5 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.006 | 0.4497 | 1 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.006 | 0.4497 | 0.5 |
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.006 | 0.4497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0 | 0.5 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0039 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0085 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.