Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | mercuric reductase, putative | 0.0053 | 0.3342 | 0.3339 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0093 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0075 | 0.6995 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0093 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0053 | 0.3342 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.2042 | 0.0969 |
Schistosoma mansoni | chromobox protein | 0.0075 | 0.6995 | 0.5487 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0093 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0093 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0053 | 0.3342 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0053 | 0.3342 | 0.2603 |
Toxoplasma gondii | thioredoxin reductase | 0.0093 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0053 | 0.3342 | 0.5 |
Brugia malayi | chromobox protein homolog 3 | 0.0042 | 0.1511 | 0.0569 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0053 | 0.3342 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0093 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0053 | 0.3342 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0075 | 0.6995 | 0.6995 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.1511 | 0.7399 |
Trypanosoma brucei | trypanothione reductase | 0.0093 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0093 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.2042 | 0.0969 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0053 | 0.3342 | 0.3339 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0093 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0075 | 0.6995 | 0.6662 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0053 | 0.3342 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0053 | 0.3342 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0075 | 0.6995 | 0.5487 |
Leishmania major | trypanothione reductase | 0.0093 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0093 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0093 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.2042 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0075 | 0.6995 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0093 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0093 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0053 | 0.3342 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1511 | 0.1511 |
Schistosoma mansoni | chromobox protein | 0.0075 | 0.6995 | 0.5487 |
Treponema pallidum | NADH oxidase | 0.0053 | 0.3342 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0075 | 0.6995 | 0.5487 |
Echinococcus multilocularis | chromobox protein 1 | 0.0075 | 0.6995 | 0.5487 |
Echinococcus granulosus | chromobox protein 1 | 0.0075 | 0.6995 | 0.5487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.