Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | nitric oxide synthase, putative | 0.0108 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0108 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0108 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0067 | 0.2291 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0096 | 0.7709 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0108 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0108 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0108 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0096 | 0.7709 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0108 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0067 | 0.2291 | 0.2291 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0108 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0108 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0108 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0108 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0108 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0108 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0108 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0108 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0108 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.