Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.008 | 0.1062 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.008 | 0.1062 | 0.1062 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0162 | 1 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0162 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1062 | 0.1062 |
Schistosoma mansoni | adenosine kinase | 0.0162 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0162 | 1 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.0162 | 1 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.0162 | 1 | 1 |
Onchocerca volvulus | 0.0144 | 0.7988 | 0.5 | |
Toxoplasma gondii | kinase, pfkB family protein | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0162 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.008 | 0.1062 | 0.1062 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.008 | 0.1062 | 0.1062 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.008 | 0.1062 | 0.1062 |
Leishmania major | adenosine kinase, putative | 0.0162 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0162 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.