Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1713 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.192 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1713 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1126 | 0.5371 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1713 | 0.8794 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.192 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.7936 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.7936 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.192 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0205 | 0.9862 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1222 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1222 | 0.1315 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1222 | 0.1315 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1222 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.7936 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.7936 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1222 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1222 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1713 | 0.195 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1126 | 0.5371 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1713 | 0.8794 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1713 | 0.195 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1222 | 0.5929 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1126 | 0.1191 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1713 | 0.195 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0012 | 0 | 0.5 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0012 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.192 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1222 | 0.1315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1713 | 0.195 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1222 | 0.1315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1713 | 0.195 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.