Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.05657 | 0.255418 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0372619 | 0.12918 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.170454 | 1 | 0.5 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0654698 | 0.313606 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.162277 | 0.94654 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0372619 | 0.12918 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0372619 | 0.12918 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0372619 | 0.12918 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0372619 | 0.12918 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0372619 | 0.12918 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0372619 | 0.12918 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0372619 | 0.12918 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0372619 | 0.12918 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0372619 | 0.12918 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0372619 | 0.12918 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0736465 | 0.367066 | 0.0844636 |
Onchocerca volvulus | Putative sulfate transporter | 0.05657 | 0.255418 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.170454 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0175038 | 0 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0175038 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.170454 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0372619 | 0.12918 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.99 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 1.9904 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 15 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | > 15 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
Percent growth inhibition (functional) | = 100.9 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 105.1 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.