Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | squalene synthase, putative | Curated by TDR Targets | No references |
Trypanosoma cruzi | squalene synthase, putative | Curated by TDR Targets | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protein kinase 7 | 0.0295 | 0 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0908 | 1 | 0.5 |
Trypanosoma brucei | squalene synthase, putative | 0.0908 | 1 | 0.5 |
Toxoplasma gondii | protein kinase, putative | 0.0295 | 0 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0908 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased (PATO:0000468) | amastigote (BTO:0000062) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 34834 | |
Annotator: | millerja@u.washington.edu | Comment: | References: | 15215084 17643987 17709461 2073100 3056256 9661019 | ||
growth (GO:0040007) | decreased (PATO:0000468) | amastigote (BTO:0000062) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 47047 | |
Annotator: | millerja@u.washington.edu | Comment: | References: | 15215084 17643987 17709461 2073100 3056256 9661019 |