Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-88 | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0103 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0103 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0103 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0103 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0103 | 0.5 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0103 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0103 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | = 8.306 ug/ml | In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in Onchocerca ochengi microfilariae | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM | WHO/TDR. | No reference |
% motility reduction (functional) | = 100 % | Motility reduction assay in Schistosoma mansoni Egyptian sambon adult worms | WHO/TDR. | No reference |
IC50 (functional) | = 3.17 ug/ml | In vitro activity against Trypanosoma brucei measured by florescence after 24h | WHO/TDR. | No reference |
IC50 (functional) | = 3.17 ug/ml | In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days | WHO/TDR. | No reference |
IC50 (functional) | = 3.17 ug/ml | WHO-TDR: Leishmaniasis | ChEMBL. | No reference |
IC50 (functional) | = 3.17 ug/ml | WHO-TDR: Human African Trypanosomiasis (HAT) | ChEMBL. | No reference |
IC50 (functional) | = 6.257 ug/ml | In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days | WHO/TDR. | No reference |
IC50 (functional) | = 6.257 ug/ml | WHO-TDR: Chagas disease | ChEMBL. | No reference |
IC50 | = 8.306 ug/ml | WHO-TDR: Cytotoxicity | ChEMBL. | No reference |
IC50 (functional) | > 9.791 ug/ml | In vitro activity against Plasmodium falciparum measured by colorimetry after 72h | WHO/TDR. | No reference |
IC50 (functional) | > 9.791 ug/ml | WHO-TDR: Malaria | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Inhibition (functional) | = 100 % | WHO-TDR: Schistosomiasis | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | |||
Leishmania infantum | ChEMBL23 | ||
Trypanosoma cruzi | ChEMBL23 | ||
Trypanosoma brucei gambiense |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.