Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily A, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Brugia malayi | ORL1-like opioid receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Brugia malayi | Melatonin receptor type 1A | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0192 | 0.9764 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | ankyrin repeat protein | 0.0192 | 0.9764 | 0.9764 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0031 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0031 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0192 | 0.9764 | 0.9764 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.7 uM | Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count | ChEMBL. | 19945872 |
pA2 (functional) | = 1.91 uM | Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced [45]Ca2+ influx by microbeta plate count | ChEMBL. | 19945872 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.