Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.0551 | 0.0791 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0066 | 0.0094 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.0617 | 0.0885 |
Brugia malayi | thymidylate synthase | 0.0672 | 0.6969 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.0634 | 0.0909 |
Onchocerca volvulus | 0.0672 | 0.6969 | 0.5 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0672 | 0.6969 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0274 | 0.2567 | 0.3684 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.0617 | 0.0885 |
Echinococcus multilocularis | thymidylate synthase | 0.0672 | 0.6969 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0946 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0672 | 0.6969 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.0617 | 0.0885 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0274 | 0.2567 | 0.3684 |
Loa Loa (eye worm) | thymidylate synthase | 0.0672 | 0.6969 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.014 | 0.1081 | 0.155 |
Brugia malayi | hypothetical protein | 0.032 | 0.3072 | 0.4408 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0946 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.032 | 0.3072 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0274 | 0.2567 | 0.3684 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0274 | 0.2567 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0274 | 0.2567 | 0.3684 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.0551 | 0.0791 |
Mycobacterium tuberculosis | Hypothetical protein | 0.032 | 0.3072 | 0.1148 |
Mycobacterium ulcerans | thymidylate synthase | 0.0672 | 0.6969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0104 | 0.015 |
Schistosoma mansoni | dihydrofolate reductase | 0.0274 | 0.2567 | 0.3684 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0946 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0617 | 0.0885 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.014 | 0.1081 | 0.155 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0672 | 0.6969 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0274 | 0.2567 | 0.3684 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0946 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0672 | 0.6969 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0946 | 1 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.0617 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.