Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0147 | 0.3148 | 0.3148 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0089 | 0.1028 | 0.1145 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.6805 | 0.7585 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.6805 | 0.7585 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.1028 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1028 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0287 | 0.8236 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.6805 | 0.7585 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0307 | 0.8972 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0089 | 0.1028 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0089 | 0.1028 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.1028 | 0.1028 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0307 | 0.8972 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0089 | 0.1028 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0335 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.6805 | 0.7585 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0307 | 0.8972 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0287 | 0.8236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.7495 | 0.8354 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0307 | 0.8972 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.01 | 0.1444 | 0.1444 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0247 | 0.6805 | 0.6805 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0247 | 0.6805 | 0.7585 |
Echinococcus granulosus | voltage gated potassium channel | 0.0089 | 0.1028 | 0.1145 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0247 | 0.6805 | 0.7585 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0247 | 0.6805 | 0.7585 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.6805 | 0.7585 |
Onchocerca volvulus | 0.0247 | 0.6805 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.2 uM | Inhibition of human ASBT expressed in MDCK cells assessed as inhibition of [3H]taurocholic acid uptake after 10 mins by liquid scintillation counting | ChEMBL. | 20504026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.