Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0063 | 0.0951 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0951 | 0.0951 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0951 | 0.0951 |
Onchocerca volvulus | 0.0063 | 0.0951 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.0951 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.0951 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.0951 | 0.0951 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0951 | 0.0951 |
Onchocerca volvulus | 0.0063 | 0.0951 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | TK protein kinase | 0.0473 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.9939 | 0.9939 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0473 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0951 | 0.0951 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.0951 | 1 |
Brugia malayi | Peroxidasin | 0.0063 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.0951 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0951 | 0.0951 |
Echinococcus granulosus | tyrosine protein kinase | 0.0473 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.0951 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.0951 | 1 |
Giardia lamblia | High cysteine protein | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.0951 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0951 | 0.0951 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.0951 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 26.15 uM | Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay | ChEMBL. | 24934992 |
IC50 (binding) | = 0.051 uM | Inhibition of COX2 (unknown origin) by solid phase ELISA method | ChEMBL. | 24934992 |
IC50 (binding) | = 10.04 uM | Inhibition of COX1 (unknown origin) by solid phase ELISA method | ChEMBL. | 24934992 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.