Detailed information for compound 916126

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.985 | Formula: C24H17ClN2O5S2
  • H donors: 3 H acceptors: 4 LogP: 5.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CN1C(=S)S/C(=C\c2cccc(c2O)O)/C1=O)Nc1ccc(cc1)Oc1ccc(cc1)Cl
  • InChi: 1S/C24H17ClN2O5S2/c25-15-4-8-17(9-5-15)32-18-10-6-16(7-11-18)26-21(29)13-27-23(31)20(34-24(27)33)12-14-2-1-3-19(28)22(14)30/h1-12,28,30H,13H2,(H,26,29)/b20-12-
  • InChiKey: DHOBLLZJXRUGFB-NDENLUEZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Thermus thermophilus Malate dehydrogenase Starlite/ChEMBL References
Escherichia coli 1-deoxy-D-xylulose 5-phosphate reductoisomerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus multilocularis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium yoelii 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Schistosoma japonicum ko:K00026 malate dehydrogenase [EC1.1.1.37B], putative Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma congolense cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS Get druggable targets OG5_130462 All targets in OG5_130462
Trypanosoma cruzi cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Entamoeba histolytica malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Loa Loa (eye worm) malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma cruzi cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Giardia lamblia Malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium berghei 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Leishmania major cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium knowlesi 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Neospora caninum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Echinococcus multilocularis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania donovani cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania infantum cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma brucei cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Chlamydia trachomatis malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Theileria parva 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras Get druggable targets OG5_130462 All targets in OG5_130462
Babesia bovis 1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein Get druggable targets OG5_130462 All targets in OG5_130462
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania braziliensis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma brucei gambiense cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative Get druggable targets OG5_127410 All targets in OG5_127410
Mycobacterium ulcerans malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Brugia malayi Malate dehydrogenase, cytoplasmic Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania mexicana cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Malate dehydrogenase   327 aa 342 aa 21.6 %
Echinococcus granulosus L lactate dehydrogenase B chain Malate dehydrogenase   327 aa 267 aa 22.1 %
Echinococcus multilocularis L lactate dehydrogenase B chain Malate dehydrogenase   327 aa 267 aa 22.1 %
Brugia malayi lactate dehydrogenase. Malate dehydrogenase   327 aa 345 aa 22.6 %
Onchocerca volvulus Malate dehydrogenase   327 aa 322 aa 53.7 %
Schistosoma mansoni malate dehydrogenase Malate dehydrogenase   327 aa 367 aa 21.8 %
Echinococcus multilocularis malate dehydrogenase 1b Malate dehydrogenase   327 aa 353 aa 23.8 %
Echinococcus granulosus malate dehydrogenase 1b Malate dehydrogenase   327 aa 364 aa 24.2 %
Entamoeba histolytica malate dehydrogenase, putative Malate dehydrogenase   327 aa 315 aa 43.5 %
Onchocerca volvulus Malate dehydrogenase   327 aa 341 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.0131 0.0689 0.0689
Echinococcus multilocularis ecdysone induced protein 78C 0.0131 0.0689 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0051 0.0049 0.071
Loa Loa (eye worm) hypothetical protein 0.0086 0.0325 0.0325
Brugia malayi steroid hormone receptor 0.0131 0.0689 0.0689
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0131 0.0689 0.0689
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.3815 1
Leishmania major cytosolic malate dehydrogenase 0.0051 0.0049 0.5
Brugia malayi hypothetical protein 0.0086 0.0325 0.0325
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0131 0.0689 0.0689
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0131 0.0689 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Echinococcus granulosus cytosolic malate dehydrogenase 0.0051 0.0049 0.071
Loa Loa (eye worm) hypothetical protein 0.0131 0.0689 0.0689
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0131 0.0689 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0131 0.0689 1
Schistosoma mansoni malate dehydrogenase 0.0051 0.0049 0.0182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0131 0.0689 0.0689
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0131 0.0689 0.0689
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0131 0.0689 0.0689
Entamoeba histolytica malate dehydrogenase, putative 0.0051 0.0049 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0131 0.0689 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0049 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0131 0.0689 1
Brugia malayi nuclear receptor RXR 0.0086 0.0325 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0131 0.0689 0.0689
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0131 0.0689 0.0689
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Brugia malayi nuclear hormone receptor 0.0131 0.0689 0.0689
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0131 0.0689 1
Loa Loa (eye worm) malate dehydrogenase 0.0051 0.0049 0.0049
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0086 0.0325 0.121
Schistosoma mansoni malate dehydrogenase 0.0051 0.0049 0.0182
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0086 0.0325 0.0325
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.3815 0.5
Loa Loa (eye worm) hypothetical protein 0.0131 0.0689 0.0689
Echinococcus granulosus cytosolic malate dehydrogenase 0.0051 0.0049 0.071
Loa Loa (eye worm) hypothetical protein 0.0086 0.0325 0.0325
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0131 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0689 0.0689
Schistosoma mansoni thyroid hormone receptor 0.0131 0.0689 0.2564
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.3815 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0325 0.0325
Onchocerca volvulus Bile acid receptor homolog 0.1289 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0131 0.0689 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0131 0.0689 0.0689
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3815 1
Schistosoma mansoni RAR-like nuclear receptor 0.0131 0.0689 0.2564
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0051 0.0049 0.071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131 0.0689 0.0689
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Schistosoma mansoni thyroid hormone receptor 0.0131 0.0689 0.2564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0131 0.0689 0.2564
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0131 0.0689 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0131 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.1289 1 1
Schistosoma mansoni nuclear hormone receptor 0.0131 0.0689 0.2564
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0131 0.0689 0.0689
Onchocerca volvulus 0.0131 0.0689 0.0689
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3815 0.5
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Brugia malayi nuclear receptor NHR-88 0.0131 0.0689 0.0689
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0131 0.0689 0.0689
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0051 0.0049 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0131 0.0689 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0131 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0325 0.0325
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0131 0.0689 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0049 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0131 0.0689 0.2564
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0049 0.5
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0051 0.0049 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0131 0.0689 0.0689
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0131 0.0689 0.2564
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0131 0.0689 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0379 0.2687 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0131 0.0689 0.0689
Brugia malayi photoreceptor-specific nuclear receptor 0.0131 0.0689 0.0689
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0051 0.0049 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0131 0.0689 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0131 0.0689 0.0689
Giardia lamblia Malate dehydrogenase 0.0051 0.0049 0.5
Trypanosoma brucei cytosolic malate dehydrogenase 0.0051 0.0049 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0131 0.0689 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0086 0.0325 0.4721
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0131 0.0689 0.2564
Brugia malayi hypothetical protein 0.0086 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0086 0.0325 0.0325
Schistosoma mansoni coup transcription factor 0.0131 0.0689 0.2564
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0051 0.0049 0.0049
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3815 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.0325 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0131 0.0689 0.0689
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0131 0.0689 0.0689
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0131 0.0689 0.0689
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.0325 0.121
Loa Loa (eye worm) hypothetical protein 0.0131 0.0689 0.0689
Echinococcus granulosus FTZ F1 alpha 0.0131 0.0689 1
Brugia malayi Nuclear hormone receptor-like 1 0.0131 0.0689 0.0689
Echinococcus multilocularis FTZ F1 alpha 0.0131 0.0689 1
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3815 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0131 0.0689 0.2564
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0131 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0131 0.0689 0.0689
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0131 0.0689 0.2564
Loa Loa (eye worm) hypothetical protein 0.0131 0.0689 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0131 0.0689 0.0689
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0131 0.0689 0.0689
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0131 0.0689 0.0689
Trichomonas vaginalis malate dehydrogenase, putative 0.0051 0.0049 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0086 0.0325 0.4721
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.0641 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0131 0.0689 0.2564
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3815 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0051 0.0049 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0131 0.0689 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0131 0.0689 0.2564
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0325 0.0325

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.7 uM Inhibition of Thermus flavus MDH pre-incubated for 4 mins before reaction initiation in presence of OAA and NAPH in absence of 0.01% Triton X100 by UV-Vis spectrophotometry ChEMBL. 24890653
IC50 (binding) = 3.3 uM Inhibition of His-tagged Escherichia coli DXR pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in absence of 0.01% Triton X100 ChEMBL. 24890653
Inhibition (binding) < 5 % Inhibition of His-tagged Escherichia coli DXR at 20 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in presence of 0.01% Triton X100 ChEMBL. 24890653
Inhibition (binding) < 5 % Inhibition of Thermus flavus MDH at 10 uM pre-incubated for 4 mins before reaction initiation in presence of OAA and NAPH in presence of 0.01% Triton X100 by UV-Vis spectrophotometry ChEMBL. 24890653
Inhibition (binding) = 43 % Inhibition of His-tagged Escherichia coli DXR at 6 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH ChEMBL. 24890653
Inhibition (binding) = 63 % Inhibition of His-tagged Escherichia coli DXR at 6 uM pre-incubated for 2 mins before reaction initiation in absence of 160 uM NADPH ChEMBL. 24890653

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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