Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0412 | 1 | 1 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0388 | 0.875 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Trypanosoma cruzi | GMP reductase | 0.0412 | 1 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Leishmania major | guanosine monophosphate reductase | 0.0412 | 1 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0308 | 0.4701 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Trypanosoma brucei | GMP reductase | 0.0412 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0412 | 1 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0412 | 1 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0412 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0412 | 1 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0412 | 1 | 1 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0388 | 0.875 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0412 | 1 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0412 | 1 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0412 | 1 | 1 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Trypanosoma cruzi | GMP reductase | 0.0412 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0412 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0412 | 1 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4701 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0308 | 0.4701 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0412 | 1 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0412 | 1 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0412 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.