Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.1236 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0832 | 0.5497 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0832 | 0.5497 | 0.5497 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0832 | 0.5497 | 0.5497 |
Onchocerca volvulus | Deterin homolog | 0.1236 | 1 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0832 | 0.5497 | 0.5497 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0832 | 0.5497 | 0.5497 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0832 | 0.5497 | 0.5497 |
Loa Loa (eye worm) | hypothetical protein | 0.1236 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0832 | 0.5497 | 0.5497 |
Brugia malayi | Protein kinase domain containing protein | 0.0832 | 0.5497 | 0.5497 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.1236 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 15.9 ug ml-1 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT method | ChEMBL. | 24657569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.