Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hemopexin family protein | 0.0031 | 0.0378 | 0.0378 |
Echinococcus granulosus | tyrosine protein kinase | 0.029 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0.0037 | 0.0364 | |
Brugia malayi | Matrixin family protein | 0.0022 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0022 | 0.0037 | 0.0037 |
Echinococcus multilocularis | tyrosine protein kinase | 0.029 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0022 | 0.0037 | 0.0037 |
Brugia malayi | Matrixin family protein | 0.0022 | 0.0037 | 0.0037 |
Brugia malayi | Matrixin family protein | 0.0053 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0215 | 0.0215 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.008 | 0.2183 | 0.2183 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0027 | 0.0215 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0049 | 0.1029 | 0.1029 |
Brugia malayi | Matrixin family protein | 0.0022 | 0.0037 | 0.0037 |
Onchocerca volvulus | 0.0031 | 0.0378 | 0.3671 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0037 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0378 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0022 | 0.0037 | 0.0993 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0049 | 0.1029 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0049 | 0.1029 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0027 | 0.0215 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0037 | 0.0037 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0027 | 0.0215 | 0.0215 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0027 | 0.0215 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.9937 | 0.9937 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.008 | 0.2183 | 0.2183 |
Loa Loa (eye worm) | matrixin family protein | 0.0053 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | TK protein kinase | 0.029 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0022 | 0.0037 | 0.0364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 108 nM | Inhibition of ROS1 (unknown origin) assessed as remaining activity | ChEMBL. | 24997577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.