Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | peroxidasin | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Toxoplasma gondii | cytochrome C oxidase subunit IIb, putative | 0.009 | 0.1117 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | 0.0297 | 0.9985 | 1 | |
Echinococcus granulosus | tyrosine protein kinase | 0.029 | 0.9682 | 0.9475 |
Mycobacterium ulcerans | cytochrome C oxidase polypeptide I CtaD | 0.0156 | 0.3936 | 1 |
Schistosoma mansoni | cytochrome c oxidase subunit II | 0.0243 | 0.769 | 0.7701 |
Mycobacterium ulcerans | cytochrome C oxidase polypeptide I CtaD | 0.0156 | 0.3936 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0297 | 0.9985 | 1 |
Plasmodium vivax | cytochrome c oxidase subunit I | 0.0156 | 0.3936 | 0.56 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Echinococcus multilocularis | peroxidasin | 0.0297 | 0.9985 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c oxidase, subunit 2 | 0.0297 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.029 | 0.9682 | 0.9696 |
Schistosoma mansoni | peroxidasin | 0.0297 | 0.9985 | 1 |
Mycobacterium tuberculosis | Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) | 0.0156 | 0.3936 | 1 |
Onchocerca volvulus | 0.0297 | 0.9985 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.9609 | 0.9623 |
Onchocerca volvulus | 0.0297 | 0.9985 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Brugia malayi | Peroxidasin | 0.0297 | 0.9985 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Onchocerca volvulus | Cytochrome c oxidase subunit 1 homolog | 0.0156 | 0.3936 | 0.3179 |
Brugia malayi | Protein kinase domain containing protein | 0.029 | 0.9682 | 0.9696 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Plasmodium falciparum | cytochrome c oxidase subunit 1 | 0.0156 | 0.3936 | 1 |
Mycobacterium leprae | PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) | 0.0156 | 0.3936 | 0.5 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0207 | 0.6151 | 1 |
Onchocerca volvulus | 0.0156 | 0.3936 | 0.3179 | |
Schistosoma mansoni | cytochrome-c oxidase | 0.009 | 0.1117 | 0.1118 |
Echinococcus granulosus | peroxidasin | 0.0297 | 0.9985 | 0.9975 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0297 | 0.9985 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Brugia malayi | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 91.5 nM | Inhibition of ROS1 (unknown origin) assessed as remaining activity | ChEMBL. | 24997577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.