Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0279 | 0.5449 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0327 | 0.8127 | 0.5885 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0327 | 0.8127 | 0.5885 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0327 | 0.8127 | 0.8127 |
Trypanosoma brucei | histone deacetylase 3 | 0.0327 | 0.8127 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0279 | 0.5449 | 0.5449 |
Echinococcus granulosus | histone deacetylase 7 | 0.0327 | 0.8127 | 0.5885 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0361 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 1 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0327 | 0.8127 | 0.5885 |
Brugia malayi | Histone deacetylase family protein | 0.0327 | 0.8127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 1 | 1 |
Trypanosoma cruzi | ion transport protein, putative | 0.0306 | 0.6921 | 0.5497 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0361 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0279 | 0.5449 | 0.5449 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0327 | 0.8127 | 1 |
Leishmania major | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0471 | 0.0471 |
Plasmodium vivax | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0279 | 0.5449 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0327 | 0.8127 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0279 | 0.5449 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0327 | 0.8127 | 0.5885 |
Leishmania major | ion transport protein-like protein | 0.0306 | 0.6921 | 0.5497 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0279 | 0.5449 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0343 | 0.9022 | 0.7852 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0327 | 0.8127 | 0.5885 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0279 | 0.5449 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.0327 | 0.8127 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0279 | 0.5449 | 0.5 |
Trypanosoma brucei | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Trypanosoma cruzi | ion transport protein, putative | 0.0306 | 0.6921 | 0.5497 |
Echinococcus granulosus | histone deacetylase 6 | 0.0327 | 0.8127 | 0.5885 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0279 | 0.5449 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0327 | 0.8127 | 0.8127 |
Echinococcus multilocularis | histone deacetylase | 0.0327 | 0.8127 | 0.5885 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.5449 | 0.5449 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0327 | 0.8127 | 0.5885 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0279 | 0.5449 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0327 | 0.8127 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0327 | 0.8127 | 0.5885 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0471 | 0.0471 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0279 | 0.5449 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0327 | 0.8127 | 0.5885 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0279 | 0.5449 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0327 | 0.8127 | 1 |
Leishmania major | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0327 | 0.8127 | 0.5885 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0327 | 0.8127 | 0.5885 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0327 | 0.8127 | 1 |
Giardia lamblia | Histone deacetylase | 0.0279 | 0.5449 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 33 uM | Inhibition of Plasmodium falciparum serine protease subtilisin-like protease 1by fluorimetric assay | ChEMBL. | 24909083 |
Inhibition (binding) | = 59 % | Inhibition of Plasmodium falciparum serine protease subtilisin-like protease 1 at 100 uM by fluorimetric assay | ChEMBL. | 24909083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.