TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 631.615 | Formula: C32H34N5O7P
H donors: 2 H acceptors: 6 LogP: 1.94 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: O=c1[nH]c(=O)n(cc1C)Cc1nnn(c1)C[C@@H]([C@@H](P(=O)(OCc1ccccc1)OCc1ccccc1)O)OCc1ccccc1
InChi: 1S/C32H34N5O7P/c1-24-17-36(32(40)33-30(24)38)18-28-19-37(35-34-28)20-29(42-21-25-11-5-2-6-12-25)31(39)45(41,43-22-26-13-7-3-8-14-26)44-23-27-15-9-4-10-16-27/h2-17,19,29,31,39H,18,20-23H2,1H3,(H,33,38,40)/t29-,31+/m0/s1
InChiKey: FECHJOIVJDMKGO-IGYGKHONSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	hypothetical protein	0.0153	0.217	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0371	0.0757
Brugia malayi	latrophilin 2 splice variant baaae	0.0031	0.0133	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0041	0.0309	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	hypothetical protein	0.0243	0.3669	0.3468
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0243	0.3669	0.3584
Onchocerca volvulus		0.0243	0.3669	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	biogenic amine 5HT receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0045	0.0371	0.0993
Brugia malayi	Dopamine receptor	0.0243	0.3669	0.9831
Onchocerca volvulus		0.0243	0.3669	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	neuropeptide F receptor	0.0243	0.3669	0.7489
Onchocerca volvulus		0.0243	0.3669	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0243	0.3669	0.9831
Brugia malayi	glutaminase DH11.1	0.0247	0.3732	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0243	0.3669	0.3468
Echinococcus multilocularis	neuropeptide receptor	0.0243	0.3669	0.3468
Mycobacterium ulcerans	hypothetical protein	0.0317	0.49	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0243	0.3669	0.3468
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0243	0.3669	0.7489
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0243	0.3669	0.3468
Brugia malayi	AKH receptor	0.0243	0.3669	0.9831
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	neuropeptide receptor	0.0243	0.3669	0.3584
Onchocerca volvulus		0.0243	0.3669	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0243	0.3669	0.9831
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0243	0.3669	0.7489
Schistosoma mansoni	neuropeptide receptor	0.0243	0.3669	0.3584
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Brugia malayi	GnHR receptor homolog	0.0243	0.3669	0.9831
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Onchocerca volvulus		0.0243	0.3669	1
Onchocerca volvulus		0.0243	0.3669	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus multilocularis	neuropeptides capa receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0243	0.3669	0.3584
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0041	0.0309	0.063
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0243	0.3669	1
Schistosoma mansoni	biogenic amine receptor	0.0243	0.3669	0.3584
Onchocerca volvulus		0.0243	0.3669	1
Echinococcus granulosus	neuropeptide Y receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0243	0.3669	0.3468
Brugia malayi	G-protein coupled receptor	0.0243	0.3669	0.9831
Echinococcus granulosus	neuropeptide s receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0243	0.3669	0.3468
Onchocerca volvulus		0.0243	0.3669	1
Loa Loa (eye worm)	TYRA-2 protein	0.0243	0.3669	0.7489
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	g protein coupled receptor	0.0243	0.3669	0.3468
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Entamoeba histolytica	hypothetical protein, conserved	0.0317	0.49	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	7TM GPCR rhodopsin	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	hypothetical protein	0.0243	0.3669	0.3584
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0243	0.3669	1
Schistosoma mansoni	hypothetical protein	0.0243	0.3669	0.3584
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0129	0.1768	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0133	0.0272
Schistosoma mansoni	amine GPCR	0.0243	0.3669	0.3584
Echinococcus granulosus	allatostatin A receptor	0.0243	0.3669	0.3468
Echinococcus granulosus	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Schistosoma mansoni	opsin-like receptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	serotonin receptor	0.0243	0.3669	0.3468
Brugia malayi	neuropeptide F receptor	0.0243	0.3669	0.9831
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Echinococcus granulosus	G protein coupled receptor 139	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	dro:myosuppressin receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0243	0.3669	0.3584
Onchocerca volvulus		0.0243	0.3669	1
Echinococcus granulosus	neuropeptides capa receptor	0.0243	0.3669	0.3468
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0243	0.3669	0.3468
Treponema pallidum	fructose-bisphosphate aldolase	0.0264	0.4017	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Loa Loa (eye worm)	G-protein coupled receptor	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0243	0.3669	0.3584
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Brugia malayi	G protein-coupled receptor F59B2.13	0.0243	0.3669	0.9831
Giardia lamblia	Fructose-bisphosphate aldolase	0.0264	0.4017	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Schistosoma mansoni	opsin-like receptor	0.0243	0.3669	0.3584
Mycobacterium tuberculosis	Conserved protein	0.0317	0.49	1
Brugia malayi	sulfakinin receptor protein	0.0243	0.3669	0.9831
Schistosoma mansoni	amine GPCR	0.0243	0.3669	0.3584
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0243	0.3669	0.3584
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0243	0.3669	0.3468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0045	0.0371	0.0757
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0243	0.3669	0.7489
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0243	0.3669	0.3584
Brugia malayi	neuropeptide F receptor	0.0243	0.3669	0.9831
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0243	0.3669	0.9831
Echinococcus granulosus	neuropeptide Y receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	sphingosine kinase 1	0.0317	0.49	0.4737
Brugia malayi	Serotonin receptor	0.0243	0.3669	0.9831
Brugia malayi	hypothetical protein	0.0136	0.1894	0.5073
Schistosoma mansoni	hypothetical protein	0.0243	0.3669	0.3584
Onchocerca volvulus		0.0243	0.3669	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.0309	0.0178
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0243	0.3669	0.3584
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0243	0.3669	0.9831
Onchocerca volvulus		0.0243	0.3669	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0243	0.3669	0.9831
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Echinococcus multilocularis	neuropeptides capa receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	hypothetical protein	0.0153	0.217	0.2064
Onchocerca volvulus		0.0243	0.3669	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0243	0.3669	0.3468
Echinococcus granulosus	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.0309	0.0178
Echinococcus multilocularis	somatostatin receptor	0.0243	0.3669	0.3468
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.0023	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	biogenic amine receptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0243	0.3669	0.3468
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	opsin-like receptor	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus multilocularis	geminin	0.0153	0.217	0.192
Schistosoma mansoni	microtubule-associated protein tau	0.0622	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Echinococcus multilocularis	dro:myosuppressin receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus multilocularis	allatostatin A receptor	0.0243	0.3669	0.3468
Echinococcus granulosus	neuropeptide FF receptor 2	0.0243	0.3669	0.3468
Echinococcus granulosus	7tm_1 domain containing protein	0.0243	0.3669	0.3468
Schistosoma mansoni	sphingoid long chain base kinase	0.0317	0.49	0.4831
Schistosoma mansoni	sphingosine kinase A B	0.0317	0.49	0.4831
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Echinococcus multilocularis	g protein coupled receptor	0.0243	0.3669	0.3468
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0243	0.3669	0.9831
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0	0.5
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Brugia malayi	Serotonin receptor	0.0243	0.3669	0.9831
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0243	0.3669	0.3468
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0243	0.3669	0.3468
Echinococcus granulosus	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Echinococcus granulosus	sex peptide receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	neuropeptide receptor	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Echinococcus multilocularis	fmrfamide receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0317	0.49	1
Echinococcus multilocularis	neuropeptide s receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0243	0.3669	0.3584
Echinococcus granulosus	neuropeptide receptor A26	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1894	0.3865
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0243	0.3669	0.3468
Echinococcus multilocularis	G protein coupled receptor 139	0.0243	0.3669	0.3468
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0243	0.3669	0.7489
Mycobacterium ulcerans	glutaminase	0.0247	0.3732	0.6273
Echinococcus granulosus	somatostatin receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	g protein coupled receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	histamine h1 receptor	0.0243	0.3669	0.3584
Echinococcus granulosus	g-protein coupled receptor	0.0243	0.3669	0.3468
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Brugia malayi	larval opioid receptor	0.0243	0.3669	0.9831
Leishmania major	hypothetical protein, conserved	0.0023	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0243	0.3669	0.3584
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Echinococcus multilocularis	neuropeptide receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	neuropeptide F-like receptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	neuropeptide Y receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Schistosoma mansoni	glutaminase	0.0247	0.3732	0.3648
Schistosoma mansoni	amine GPCR	0.0243	0.3669	0.3584
Brugia malayi	ORL1-like opioid receptor	0.0243	0.3669	0.9831
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Echinococcus granulosus	serotonin receptor	0.0243	0.3669	0.3468
Onchocerca volvulus		0.0243	0.3669	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	glutaminase 2	0.0247	0.3732	0.7618
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	fmrfamide receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0243	0.3669	0.7489
Echinococcus granulosus	tm gpcr rhodopsin	0.0243	0.3669	0.3468
Echinococcus multilocularis	g protein coupled receptor	0.0243	0.3669	0.3468
Schistosoma mansoni	hypothetical protein	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	adenoreceptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0243	0.3669	0.3468
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0243	0.3669	0.3584
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0	0.5
Brugia malayi	G protein-coupled receptor	0.0243	0.3669	0.9831
Echinococcus multilocularis	microtubule associated protein 2	0.0622	1	1
Echinococcus granulosus	orexin receptor type 2	0.0243	0.3669	0.3468
Brugia malayi	Dopamine receptor protein 2	0.0243	0.3669	0.9831
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Loa Loa (eye worm)	neuropeptide F receptor	0.0243	0.3669	0.7489
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Onchocerca volvulus		0.0243	0.3669	1
Brugia malayi	G-protein coupled receptor	0.0243	0.3669	0.9831
Schistosoma mansoni	neuropeptide receptor	0.0243	0.3669	0.3584
Echinococcus granulosus	biogenic amine 5HT receptor	0.0243	0.3669	0.3468
Onchocerca volvulus		0.0243	0.3669	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0243	0.3669	0.3468
Brugia malayi	Dopamine receptor protein 1	0.0243	0.3669	0.9831
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0243	0.3669	0.3468
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0264	0.4017	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0243	0.3669	0.3584
Schistosoma mansoni	myosin xvIII	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.0309	0.0178
Brugia malayi	RE15519p	0.0243	0.3669	0.9831
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	neuropeptide F-like receptor	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Brugia malayi	follicle stimulating hormone receptor	0.0243	0.3669	0.9831
Loa Loa (eye worm)	G-protein coupled receptor	0.0243	0.3669	0.7489
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Echinococcus granulosus	geminin	0.0153	0.217	0.192
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus multilocularis	sex peptide receptor	0.0243	0.3669	0.3468
Brugia malayi	putative neuropeptide receptor	0.0243	0.3669	0.9831
Schistosoma mansoni	neuropeptide f receptor 76f	0.0243	0.3669	0.3584
Schistosoma mansoni	amine GPCR	0.0243	0.3669	0.3584
Onchocerca volvulus		0.0243	0.3669	1
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus granulosus	tm gpcr rhodopsin	0.0243	0.3669	0.3468
Echinococcus granulosus	sphingosine kinase 1	0.0317	0.49	0.4737
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Echinococcus multilocularis	neuropeptide receptor A26	0.0243	0.3669	0.3468
Schistosoma mansoni	biogenic amine receptor	0.0243	0.3669	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Brugia malayi	hypothetical protein	0.0243	0.3669	0.9831
Trypanosoma brucei	PAB1-binding protein , putative	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Loa Loa (eye worm)	glutaminase	0.0247	0.3732	0.7618
Brugia malayi	Melatonin receptor type 1A	0.0243	0.3669	0.9831
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0243	0.3669	0.9831
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0243	0.3669	0.3584
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0243	0.3669	0.3468
Echinococcus granulosus	neuropeptide receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0243	0.3669	0.3468
Echinococcus multilocularis	orexin receptor type 2	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Onchocerca volvulus		0.0243	0.3669	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0243	0.3669	0.3468
Echinococcus granulosus	rhodopsin orphan GPCR	0.0243	0.3669	0.3468
Schistosoma mansoni	amine GPCR	0.0243	0.3669	0.3584
Echinococcus granulosus	neuropeptides capa receptor	0.0243	0.3669	0.3468
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0045	0.0371	0.0993
Echinococcus granulosus	fmrfamide receptor	0.0243	0.3669	0.3468
Echinococcus granulosus	g protein coupled receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	serotonin receptor	0.0243	0.3669	0.3468
Echinococcus multilocularis	g-protein coupled receptor	0.0243	0.3669	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0243	0.3669	0.7489
Schistosoma mansoni	growth hormone secretagogue receptor	0.0243	0.3669	0.3584
Plasmodium vivax	ataxin-2 like protein, putative	0.0023	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0243	0.3669	0.3468

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 83 uM	Cytostatic activity against human CEM cells assessed as inhibition of proliferation after 72 hrs by Coulter cell counting method	ChEMBL.	24906510
IC50 (functional)	= 85 uM	Cytostatic activity against mouse L1210 cells assessed as inhibition of proliferation after 48 hrs by Coulter cell counting method	ChEMBL.	24906510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3310938

Bibliographic References

No literature references available for this target.

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Detailed information for compound 917555