Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0029 | 0.0111 |
Echinococcus multilocularis | snurportin 1 | 0.0303 | 0.2095 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0995 | 0.7226 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0056 | 0.0266 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0056 | 0.0212 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0374 | 0.2619 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0374 | 0.2619 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0029 | 0.0111 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0056 | 0.0212 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0029 | 0.0111 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0029 | 0.0111 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0056 | 0.0212 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0029 | 0.0139 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0016 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.2095 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0016 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0303 | 0.2095 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0056 | 0.0212 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0374 | 0.2619 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0374 | 0.2619 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0374 | 0.2619 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0374 | 0.2619 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0056 | 0.0266 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0056 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0056 | 0.0266 |
Echinococcus granulosus | snurportin 1 | 0.0303 | 0.2095 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0029 | 0.0111 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0056 | 0.0266 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0056 | 0.0212 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0029 | 0.0111 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0374 | 0.2619 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0016 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0016 | 0.006 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0029 | 0.0111 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0444 | 0.0615 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0029 | 0.004 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0016 | 0.006 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0374 | 0.2619 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0029 | 0.0111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 4.5 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR | ChEMBL. | 24881566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.