Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-cell CLL/lymphoma 2 | Starlite/ChEMBL | References |
Homo sapiens | BCL2-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | EGFP:Bcl2 fusion protein | Get druggable targets OG5_139665 | All targets in OG5_139665 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | Get druggable targets OG5_139665 | All targets in OG5_139665 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aminopeptidase, putative | 0.0253 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0771 | 0.8533 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0835 | 0.9582 | 0.9582 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0253 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0253 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0253 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0253 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0253 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0253 | 0 | 0.5 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0835 | 0.9582 | 0.9582 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0253 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0696 | 0.7295 | 0.8549 |
Entamoeba histolytica | aminopeptidase, putative | 0.0253 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0253 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0253 | 0 | 0.5 |
Onchocerca volvulus | 0.086 | 1 | 1 | |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0253 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.086 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0253 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0253 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.27 uM | Inhibition of c-terminal 6xHis-tagged Bcl-2 (amino acids 1 to 204) (unknown origin) preincubated for 1 hr prior to substrate addition measured after 20 mins by fluorescence polarization assay | ChEMBL. | 24881567 |
IC50 (binding) | = 0.378 uM | Inhibition of c-terminal 6xHis-tagged Bcl-xL (amino acids 1 to 209) (unknown origin) preincubated for 1 hr prior to substrate addition measured after 20 mins by fluorescence polarization assay | ChEMBL. | 24881567 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.