Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0895 | 0.6944 | 0.9421 |
Onchocerca volvulus | 0.0399 | 0 | 0.5 | |
Onchocerca volvulus | 0.0399 | 0 | 0.5 | |
Onchocerca volvulus | 0.0399 | 0 | 0.5 | |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0925 | 0.737 | 1 |
Onchocerca volvulus | 0.0399 | 0 | 0.5 | |
Schistosoma mansoni | tyrosinase precursor | 0.1113 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0925 | 0.737 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by twofold dilution method | ChEMBL. | 20488716 |
IC90 (functional) | > 100 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by twofold dilution method | ChEMBL. | 20488716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.