Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0119 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0006 | 0.0017 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0254 | 0.0688 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0254 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0119 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0429 | 0.1161 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0119 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0254 | 0.0688 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1933 | 0.1933 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0119 | 0.0321 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0254 | 0.0254 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0119 | 0.0321 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0119 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0429 | 0.1161 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0119 | 1 |
Loa Loa (eye worm) | zinc finger protein | 0.0306 | 0.3691 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1933 | 1 |
Echinococcus granulosus | zinc finger transcription factor gli2 | 0.0306 | 0.3691 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.1933 | 0.5236 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0 | 0.0002 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0119 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0254 | 0.1315 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0429 | 0.1161 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0254 | 0.1315 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0254 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0254 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0429 | 0.1161 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.023 | 0.1191 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1933 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0254 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.023 | 0.0624 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0119 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.023 | 0.0624 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0 | 0.0001 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0306 | 0.3691 | 1 |
Echinococcus multilocularis | zinc finger transcription factor gli2 | 0.0306 | 0.3691 | 0.3691 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0 | 0.0001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0119 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 35 uM | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 24961641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.