Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Onchocerca volvulus | 0.0053 | 0.2903 | 0.3431 | |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0038 | 0.1909 | 0.1909 |
Brugia malayi | Matrixin family protein | 0.0091 | 0.5283 | 0.5283 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Mycobacterium ulcerans | hydrolase | 0.0046 | 0.2428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2428 | 0.2428 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2903 | 0.2903 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0046 | 0.2428 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Loa Loa (eye worm) | matrixin family protein | 0.0084 | 0.4807 | 0.4807 |
Toxoplasma gondii | cathepsin B | 0.0055 | 0.2985 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0055 | 0.2985 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0137 | 0.8181 | 0.8181 |
Onchocerca volvulus | Matrilysin homolog | 0.0084 | 0.4807 | 1 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0084 | 0.4807 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0038 | 0.1909 | 0.1909 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | matrixin family protein | 0.0091 | 0.5283 | 0.5283 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0055 | 0.2985 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0137 | 0.8181 | 0.8181 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0046 | 0.2428 | 0.2428 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0055 | 0.2985 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0055 | 0.2985 | 0.2985 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0053 | 0.2903 | 0.2903 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.009 | 0.5181 | 0.5181 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0046 | 0.2428 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0055 | 0.2985 | 0.2985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26 uM | Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assay | ChEMBL. | 24960234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.