Detailed information for compound 920499

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 4 LogP: 2.94 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccnc(n1)SC1=C(O)CC(CC1=O)c1ccccc1
  • InChi: 1S/C17H16N2O2S/c1-11-7-8-18-17(19-11)22-16-14(20)9-13(10-15(16)21)12-5-3-2-4-6-12/h2-8,13,20H,9-10H2,1H3
  • InChiKey: FTKQUSDCWNCAIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lactate dehydrogenase C Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma japonicum L-lactate dehydrogenase B chain, putative Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania donovani malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma japonicum ko:K00016 L-lactate dehydrogenase [EC1.1.1.27], putative Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium berghei L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma japonicum L-lactate dehydrogenase A chain, putative Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus granulosus L lactate dehydrogenase B chain Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma mansoni L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis lactate dehydrogenase protein Get druggable targets OG5_126911 All targets in OG5_126911
Neospora caninum Malate dehydrogenase (EC 1.1.1.37), related Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus granulosus lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium knowlesi malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Toxoplasma gondii lactate dehydrogenase LDH2 Get druggable targets OG5_126911 All targets in OG5_126911
Theileria parva L-lactate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania major malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania braziliensis malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Entamoeba histolytica malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis L lactate dehydrogenase B chain Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus granulosus lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Toxoplasma gondii malate dehydrogenase MDH Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium falciparum L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania infantum malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Cryptosporidium hominis malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium knowlesi L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Neospora caninum Malate dehydrogenase (NAD) (EC 1.1.1.37) (Precursor), related Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus granulosus lactate dehydrogenase protein Get druggable targets OG5_126911 All targets in OG5_126911
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium yoelii l-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium vivax malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma japonicum ko:K00016 L-lactate dehydrogenase [EC1.1.1.27], putative Get druggable targets OG5_126911 All targets in OG5_126911
Neospora caninum Malate dehydrogenase (EC 1.1.1.37), related Get druggable targets OG5_126911 All targets in OG5_126911
Cryptosporidium parvum lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium yoelii malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Cryptosporidium hominis lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Toxoplasma gondii lactate dehydrogenase LDH1 Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania mexicana malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Brugia malayi lactate dehydrogenase. Get druggable targets OG5_126911 All targets in OG5_126911
Cryptosporidium parvum malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium vivax lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis L lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus granulosus L lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Babesia bovis lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium falciparum malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum lactate dehydrogenase, putative lactate dehydrogenase C 332 aa 307 aa 29.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0063 1 1
Echinococcus granulosus lactate dehydrogenase a 0.0056 0.7494 0.7494
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus granulosus neuropeptide receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0063 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Onchocerca volvulus 0.0063 1 0.5
Echinococcus multilocularis allatostatin A receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0063 1 1
Echinococcus granulosus somatostatin receptor 0.0063 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0063 1 1
Schistosoma mansoni hypothetical protein 0.0063 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0063 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0063 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0063 1 1
Brugia malayi follicle stimulating hormone receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Schistosoma mansoni amine GPCR 0.0063 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0063 1 1
Echinococcus granulosus fmrfamide receptor 0.0063 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0063 1 1
Echinococcus granulosus g protein coupled receptor 0.0063 1 1
Brugia malayi neuropeptide F receptor 0.0063 1 1
Echinococcus multilocularis somatostatin receptor 0.0063 1 1
Schistosoma mansoni neuropeptide receptor 0.0063 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0063 1 1
Brugia malayi AKH receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Toxoplasma gondii lactate dehydrogenase LDH1 0.0056 0.7494 0.5
Brugia malayi larval opioid receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis neuropeptide receptor 0.0063 1 1
Echinococcus multilocularis serotonin receptor 0.0063 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0063 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0063 1 1
Echinococcus granulosus hypothetical protein 0.0063 1 1
Echinococcus multilocularis lactate dehydrogenase a 0.0056 0.7494 0.7494
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0063 1 1
Schistosoma mansoni amine GPCR 0.0063 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0063 1 1
Echinococcus multilocularis neuropeptide receptor 0.0063 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Schistosoma mansoni opsin-like receptor 0.0063 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0063 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Schistosoma mansoni biogenic amine receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Schistosoma mansoni biogenic amine receptor 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Echinococcus granulosus sex peptide receptor 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Schistosoma mansoni hypothetical protein 0.0063 1 1
Brugia malayi G-protein coupled receptor 0.0063 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Brugia malayi G-protein coupled receptor 0.0063 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0063 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0063 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0063 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0063 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0063 1 1
Echinococcus granulosus serotonin receptor 0.0063 1 1
Brugia malayi Dopamine receptor protein 1 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis fmrfamide receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0063 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0063 1 1
Brugia malayi ORL1-like opioid receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Brugia malayi neuropeptide F receptor 0.0063 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 1 1
Schistosoma mansoni amine GPCR 0.0063 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0063 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0063 1 1
Plasmodium falciparum L-lactate dehydrogenase 0.0056 0.7494 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0063 1 1
Schistosoma mansoni neuropeptide receptor 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0063 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 1 1
Echinococcus granulosus g protein coupled receptor 0.0063 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0063 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0063 1 1
Brugia malayi Dopamine receptor 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0063 1 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus granulosus lactate dehydrogenase protein 0.0056 0.7494 0.7494
Echinococcus multilocularis lactate dehydrogenase a 0.0056 0.7494 0.7494
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Echinococcus multilocularis g protein coupled receptor 0.0063 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0063 1 1
Toxoplasma gondii malate dehydrogenase MDH 0.0056 0.7494 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Brugia malayi sulfakinin receptor protein 0.0063 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0063 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Schistosoma mansoni amine GPCR 0.0063 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0063 1 1
Brugia malayi Melatonin receptor type 1A 0.0063 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis g protein coupled receptor 0.0063 1 1
Entamoeba histolytica malate dehydrogenase, putative 0.0056 0.7494 0.5
Plasmodium vivax lactate dehydrogenase 0.0056 0.7494 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0063 1 1
Schistosoma mansoni neuropeptide receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus multilocularis g protein coupled receptor 0.0063 1 1
Schistosoma mansoni myosin xvIII 0.0063 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 1 1
Brugia malayi putative neuropeptide receptor 0.0063 1 1
Brugia malayi RE15519p 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Brugia malayi Serotonin receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0063 1 1
Schistosoma mansoni hypothetical protein 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 1 1
Echinococcus granulosus g-protein coupled receptor 0.0063 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0063 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0063 1 1
Schistosoma mansoni opsin-like receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis sex peptide receptor 0.0063 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0063 1 1
Echinococcus granulosus L lactate dehydrogenase B chain 0.0056 0.7494 0.7494
Loa Loa (eye worm) G-protein coupled receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0056 0.7494 0.7494
Echinococcus multilocularis G protein coupled receptor 139 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0063 1 1
Echinococcus multilocularis orexin receptor type 2 0.0063 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0063 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0063 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 1 1
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0056 0.7494 0.5
Echinococcus multilocularis fmrfamide receptor 0.0063 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0063 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 1 1
Echinococcus granulosus lactate dehydrogenase a 0.0056 0.7494 0.7494
Schistosoma mansoni amine GPCR 0.0063 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0063 1 1
Brugia malayi Dopamine receptor protein 2 0.0063 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0063 1 1
Brugia malayi GnHR receptor homolog 0.0063 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0063 1 1
Brugia malayi G protein-coupled receptor 0.0063 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 1 1
Schistosoma mansoni adenoreceptor 0.0063 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0063 1 1
Echinococcus multilocularis lactate dehydrogenase protein 0.0056 0.7494 0.7494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0063 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0063 1 1
Schistosoma mansoni opsin-like receptor 0.0063 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 1 1
Echinococcus granulosus g protein coupled receptor 0.0063 1 1
Schistosoma mansoni histamine h1 receptor 0.0063 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0063 1 1
Echinococcus granulosus neuropeptide receptor 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Plasmodium vivax malate dehydrogenase, putative 0.0056 0.7494 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0063 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0063 1 1
Echinococcus multilocularis lactate dehydrogenase a 0.0056 0.7494 0.7494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0063 1 1
Schistosoma mansoni hypothetical protein 0.0063 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0063 1 1
Leishmania major malate dehydrogenase, putative 0.0056 0.7494 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0063 1 1
Brugia malayi Serotonin receptor 0.0063 1 1
Toxoplasma gondii lactate dehydrogenase LDH2 0.0056 0.7494 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0063 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0063 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Schistosoma mansoni neuropeptide receptor 0.0063 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0063 1 1
Echinococcus granulosus allatostatin A receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus granulosus orexin receptor type 2 0.0063 1 1
Schistosoma mansoni biogenic amine receptor 0.0063 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0063 1 1
Plasmodium falciparum malate dehydrogenase 0.0056 0.7494 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Echinococcus multilocularis serotonin receptor 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1
Onchocerca volvulus 0.0063 1 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0063 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0063 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0063 1 1
Echinococcus granulosus neuropeptide s receptor 0.0063 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 1 1
Brugia malayi hypothetical protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.3 uM Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay ChEMBL. 25037916

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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