Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | histone deacetylase, putative | histone deacetylase 3 | 428 aa | 374 aa | 30.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.0993 | 0.0993 |
Trichomonas vaginalis | AGC family protein kinase | 0.0575 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.0993 | 0.0993 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.0993 | 0.0993 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.0993 | 1 |
Plasmodium vivax | serine/threonine protein kinase, putative | 0.0575 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.0993 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0022 | 0 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.0993 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 0.0993 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.0993 | 0.0993 |
Entamoeba histolytica | histone deacetylase, putative | 0.0077 | 0.0993 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.0993 | 0.0993 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0575 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0993 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0572 | 0.9954 | 0.9954 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.0993 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 0.0993 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0993 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.0993 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 0.0993 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 0.0993 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 0.0993 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 0.0993 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.0993 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.0993 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0077 | 0.0993 | 0.0993 |
Trichomonas vaginalis | STE family protein kinase | 0.0575 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0993 | 1 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0575 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0575 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12 uM | Inhibition of HDAC3 (unknown origin) | ChEMBL. | 25042254 |
IC50 (binding) | = 28 uM | Inhibition of HDAC8 (unknown origin) | ChEMBL. | 25042254 |
IC50 (binding) | = 32 uM | Inhibition of HDAC6 (unknown origin) | ChEMBL. | 25042254 |
IC50 (binding) | = 33 uM | Inhibition of HDAC2 (unknown origin) | ChEMBL. | 25042254 |
IC50 (binding) | = 59 uM | Inhibition of HDAC1 (unknown origin) | ChEMBL. | 25042254 |
IC50 (binding) | = 74 uM | Inhibition of HDAC11 (unknown origin) | ChEMBL. | 25042254 |
IC50 (binding) | = 85 uM | Inhibition of HDAC10 (unknown origin) | ChEMBL. | 25042254 |
Inhibition (binding) | = 50 % | Inhibition of HDAC in human K562 cells nuclear extracts at 100 uM | ChEMBL. | 25042254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.