Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Deterin homolog | 0.0294 | 0.2972 | 0.2972 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0798 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0798 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0798 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0798 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0798 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0294 | 0.2972 | 0.2972 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0798 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0798 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0294 | 0.2972 | 0.2972 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.2972 | 0.2972 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0294 | 0.2972 | 0.2972 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 74 % | Inhibition of human active insulin receptor tyrosine kinase domain (amino acids 1005 to 1310) assessed as residual autophosphorylation level at 400 uM using 1000 uM ATP and insulin by BCIP/NBT staining based colorimetry and immunoblotting | ChEMBL. | 25127870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.