Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0349 | 1 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase, putative | 0.0349 | 1 | 0.5 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0349 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0349 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0349 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0349 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 112.46 uM | Anticancer activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT microcultured tetrazolium assay | ChEMBL. | 25096298 |
IZ (functional) | = 8 mm | Antifungal activity against Candida albicans MTCC 183 at 150 ug/ml after 48 hrs by agar well diffusion method | ChEMBL. | 25096298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.