Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0385 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0385 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Onchocerca volvulus | 0.0385 | 1 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0178 | 0.1195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.7 nM | Inhibition of human recombinant carbonic anhydrase 9 by stopped flow CO2 hydration method | ChEMBL. | 25019479 |
Ki (binding) | = 16.5 nM | Inhibition of human recombinant carbonic anhydrase 12 by stopped flow CO2 hydration method | ChEMBL. | 25019479 |
Ki (binding) | > 20000 nM | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | ChEMBL. | 25019479 |
Ki (binding) | > 20000 nM | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | ChEMBL. | 25019479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.