Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.1676 | 0.5 | 0.5 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.1676 | 0.5 | 0.5 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.1676 | 0.5 | 0.5 |
Toxoplasma gondii | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.1676 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.1676 | 0.5 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.1676 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS | 0.1676 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.5 ug ml-1 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv after 7 days by serial two fold dilution method | ChEMBL. | 25063947 |
MIC (functional) | > 1 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 10538 after 18 hrs by serial microdilution method | ChEMBL. | 25063947 |
MIC (functional) | > 1 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 after 18 hrs by serial microdilution method | ChEMBL. | 25063947 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.