Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0356 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0119 | 0.2632 | 0.373 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0119 | 0.2632 | 0.373 |
Trichomonas vaginalis | STE family protein kinase | 0.0356 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0262 | 0.7057 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0119 | 0.2632 | 0.0146 |
Schistosoma mansoni | tyrosine kinase | 0.0262 | 0.7057 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0262 | 0.7057 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0119 | 0.2632 | 0.0146 |
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 0.343 | 0.1803 |
Plasmodium vivax | serine/threonine protein kinase, putative | 0.0356 | 1 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0262 | 0.7057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.3365 | 0.1655 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0197 | 0.5067 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0262 | 0.7057 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0262 | 0.7057 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0262 | 0.7057 | 1 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0197 | 0.5067 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0262 | 0.7057 | 1 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0356 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0119 | 0.2632 | 0.0146 |
Trichomonas vaginalis | AGC family protein kinase | 0.0356 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0356 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 32 nM | Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay | ChEMBL. | 25119815 |
IC50 (binding) | = 32 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 32 nM | Inhibition Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.